The patient was a 46-year-old Japanese man who had met
the DSMIV diagnosis of schizophrenia, disorganized-type, for the prior 30
years. He had been on antipsychotic regimens since being diagnosed when he was
16 years old. He had been treated with therapeutic doses of sulpiride,
haloperidol, levomepromazine, risperidone, olanzapine, aripiprazole, or lithium
on several occasions, after which the treatments were stopped due to inadequate
treatment response.
After that, clozapine was started during his eighth
hospitalization in 33-year-old in which he was brought to the hospital for
persistent auditory hallucinations, monologia, persecutory delusion
aggressiveness, and psychomotor excitement. (Read more)
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