Most of the physiological functions of human body vary daily and this variation leads to changes in diseased state and in plasma drug concentration also. Due to the peak level of hormones in the body leads to disturbed sleep and increased pain. Human sleep activity cycle or solar/lunar adaptations depends on circadian rhythm and influenced by individual’s genetic makeup is responsible to affect the physiological functions.
The human circadian rhythm is also responsible for variation of physiological functions in certain diseased states such as depression, rheumatoid arthritis, myocardial infarction, peptic ulcer etc. Many body functions such as metabolism, sleep pattern, hormone production and physiology are regulated by changed environmental factors due to biological rhythms.
The human circadian rhythm is also responsible for variation of physiological functions in certain diseased states such as depression, rheumatoid arthritis, myocardial infarction, peptic ulcer etc. Many body functions such as metabolism, sleep pattern, hormone production and physiology are regulated by changed environmental factors due to biological rhythms.
These physiological variations are predictable resonating dynamic systems, which require varied amount of drug at predictably different times within the circadian cycle in order to achieve maximum desired and minimum undesired therapeutic drug effect. To meet the therapeutics need of the treatment based on pathological diseases, chronotherapeutic drug delivery systems is the best alternative way to deliver the drug.
Some of the hormones such as estrogen and progesterone are released by the brain during the morning time, while melatonin and cortisol are released during sleep. The physiological abnormalities such as blood pressure and heart rate are highest during the morning hours and hence, most diseased symptoms occur during this period.
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